Structure-guided reprogramming of DELLA turnover for a sustainable Green Revolution in rice
发布时间：2026-09-06
点击次数：
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影响因子：
18.1
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DOI码：
10.1038/s41467-026-75068-8
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发表刊物：
nature communications
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摘要：
The Green Revolution of the 1960s significantly boosted cereal yields but
incurred substantial environmental costs due to overreliance on chemical fer
tilizer inputs; thus, future agricultural sustainability demands improved
nitrogen-use efficiency (NUE). The semi-dwarf Green Revolution varieties
(GRVs) characterized by elevated DELLA protein accumulation introduce a
fundamental trade-off, increasing lodging resistance and harvest index at the
expense of diminished biomass and grain productivity per plant, and require
high nitrogen fertilizer inputs to achieve maximum yield potential under high
planting density. Here we show that gibberellin (GA)-bound GA-INSENSITIVE
DWARF1 (GID1) induces multi-level conformational changes in DELLA protein,
affecting its N-terminal DELLA and VHYN/DPT/S and C-terminal VVLV and SAW
motifs, thereby facilitating recognition by the SKP1-CULLIN-F-box (SCF) ubi
quitin ligase complex and subsequent proteasomal degradation. We also per
formed structure-guided engineering of the rice SLENDER RICE1 (SLR1)-GID1
GID2 complex and created a series of dwarf alleles exhibiting a continuous
spectrum of plant heights in elite cultivars. Notably, the dominant alleles slr1Y94A
and slr1Y580A achieved superior yield and enhanced NUE over conventional sd1
containing GRVs. Reprogramming DELLA turnover thus enables to break the
long-standing trade-off between high yield and fertilizer dependency, offering a
strategy toward a more sustainable and productive Green Revolution.
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论文类型：
期刊论文
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学科门类：
理学
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是否译文：
否
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发表时间：
2026-07-02
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收录刊物：
SCI
